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Hippocampal operation has been traditionally viewed from the tri-synaptic microcircuit perspective. Following our recent discovery of a functional regionalization of CA1 pyramidal cell activity during hippocampal ripples in deep and superficial CA1 sublayers (Valero et al. Nat Neu 2015), we aim to understand the neurophysiological basis and cognitive implications. We are now embarked in better understading how deep and superficial sublayers operate and what different role they play in cognition.

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