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The proximodistal axis is considered a major organizational principle of the hippocampus. The CA2 region apparently breaks this rule. We discovered that CA2 is organized around the limit of the mossy fibers (Fernandez-Lamo et al., Cell Reports 2019). We found a characteristic molecular gradient within CA2 and marked proximodistal trends of synaptic activity and phase-locked theta and gamma firing.  Our data suggest that the structure and function of CA2 are distributed along the proximodistal hippocampal axis.

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