Cell-type pro-sclerotic trajectories
Temporal lobe epilepsy is associated with hippocampal sclerosis, which is characterized by specific patterns of neuronal loss along hippocampal subfields from the CA1 to […]
Read MoreProximodistal organization of CA2
The proximodistal axis is considered a major organizational principle of the hippocampus. The CA2 region apparently breaks this rule. We discovered that CA2 is […]
Read MoreSublayer organization of CA1 replay
Recently, we discovered that deep and superficial CA1 pyramidal cells participate differentially during sharp-wave ripples (Valero et al Nat Neu 2015). Using unsupervised clustering […]
Read MoreMechanisms of epileptic fast ripples
Fast ripples are high-frequency oscillations (HFOs) >250 Hz recorded in epileptogenic hippocampal regions. In 2007, we proposed a mechanism by which fast ripples emerge […]
Read MorePopulation activity thresholds
Generation of population activities such as hippocampal sharp wave ripples and epileptiform discharges follows an emergent dynamics. During my postdoc, we discovered that population […]
Read MoreUbiquity of immature population bursts
The idea of a critical period in hippocampal postnatal development characterized by hyperexcitability was a major research line in the 90s. Giant Depolarizing Potentials […]
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