Microcircuit signatures of brain metastasis

In people suffering brain metastasis, cognitive impairment has been traditionally thought to result from the mass effect of the tumor growth.  Recently, we teamed […]

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Cell-type pro-sclerotic trajectories

Temporal lobe epilepsy is associated with hippocampal sclerosis, which is characterized by specific patterns of neuronal loss along hippocampal subfields from the CA1 to […]

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Proximodistal organization of CA2

The proximodistal axis is considered a major organizational principle of the hippocampus. The CA2 region apparently breaks this rule. We discovered that CA2 is […]

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Sublayer organization of CA1 replay

Recently, we discovered that the CA1 hippocampal layer is functionally heterogenous and differently engage in ongoing oscillations. Using in vivo recordings, we found that […]

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Mechanisms of epileptic fast ripples

Fast ripples are high-frequency oscillations (HFOs) >250 Hz recorded in epileptogenic hippocampal regions. In 2007, we proposed a mechanism by which fast ripples emerge […]

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Population activity thresholds

Generation of population activities such as hippocampal sharp wave ripples and epileptiform discharges follows an emergent dynamics. During my postdoc, we discovered that population […]

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Ubiquity of immature population bursts

The idea of a critical period in hippocampal postnatal development characterized by hyperexcitability was a major research line in the 90s. Giant Depolarizing Potentials […]

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