Discoveries

Microcircuit signatures of brain metastasis

In people suffering brain metastasis, cognitive impairment has been traditionally thought to result from the mass effect of the tumor growth. Recently, we teamed […]

Cell-type pro-sclerotic trajectories

Temporal lobe epilepsy is associated with hippocampal sclerosis, which is characterized by specific patterns of neuronal loss along hippocampal subfields from the CA1 to […]

Proximodistal organization of CA2

The proximodistal axis is considered a major organizational principle of the hippocampus. The CA2 region apparently breaks this rule. We discovered that CA2 is […]

Sublayer organization of CA1 replay

Recently, we discovered that deep and superficial CA1 pyramidal cells participate differentially during sharp-wave ripples (Valero et al Nat Neu 2015). Using unsupervised clustering […]

Mechanisms of epileptic fast ripples

Fast ripples are high-frequency oscillations (HFOs) >250 Hz recorded in epileptogenic hippocampal regions. In 2007, we proposed a mechanism by which fast ripples emerge […]

Population activity thresholds

Generation of population activities such as hippocampal sharp wave ripples and epileptiform discharges follows an emergent dynamics. During my postdoc, we discovered that population […]

Ubiquity of immature population bursts

The idea of a critical period in hippocampal postnatal development characterized by hyperexcitability was a major research line in the 90s. Giant Depolarizing Potentials […]